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|Amounts to be administered and administration route Spot-on use. The use of the veterinary medicinal product should exclusively be based on the confirmed mixed infestations or significant risk of such mixed infestations with ectoparasites and nematodes (including for heartworm disease prevention), and where concurrent treatment against cestodes is indicated. In the absence of risk of co-infestation, the use of a narrow spectrum parasiticide should be considered as a first line therapy. The rationale for prescription should be tailored to the individual needs of the cat, based on clinical assessment, the animal's lifestyle and on the local epidemiological situation (including zoonotic risks, where relevant) in order to address exclusively situations of mixed infestations/risk of infestation. Treatment should not be extrapolated from one animal to the other without veterinary opinion. Dosage: The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel. Select the appropriate applicator size for the weight of the cat. Weight (kg) Dosage less than 2.5 1 x 0.3 ml applicator 2.5 - 7.5 1 x 0.9 ml applicator more than 7.5 Appropriate combination of applicators Method of administration: Use a pair of scissors to cut the blister along the dotted line, then pull the lid away. Remove the applicator from the package and hold it upright. Pull back the plunger slightly, twist and pull the cap off. Part the hair on the midline of the neck, between the base of the skull and the shoulder blades until the skin is visible. Place the tip of the applicator on the skin and apply the entire content directly onto the skin in one spot. Prevention of heartworm disease (Dirofilaria immitis larvae) should start within 1 month after the first expected exposure to mosquitoes. For treatment against Aelurostrongylus abstrusus, a second administration one month after the initial treatment may be recommended. Overdose Safety has been demonstrated with up to 5 times the maximum exposure dose (i.e. up to 15 times the recommended dose) in healthy kittens aged 7 weeks and older treated up to 6 times at four-week intervals. It has also been confirmed in healthy adult cats treated 3 times at two-week intervals with up to 5 times the recommended dose. Mild and transient neurological signs such as ataxia, disorientation, apathy and pupil dilation may be observed, with spontaneous recovery the day after. Transient salivation and/or vomiting could also be observed, in both kittens and adult cats, in isolated cases. Cats infected with adult heartworms tolerated up to 3 times the maximum exposure dose (i.e. up to 9 times the recommended dose), every 4 weeks for 3 treatments, without any adverse effects.