Target species
Cattle.
Indications for use
In cattle: For the treatment of infections with the following parasites
Gastro-intestinal worms -
Haemonchus placei (adult andL4)
Ostertagia ostertagi (adult and L4, including inhibited larvae)
Trichostrongylus axei (adult and L4)
Trichostrongylus colubriformis (adult and L4)
Cooperia punctata (adult only)
Cooperia oncophora (adult only)
Strongyloides papillosus (adult only)
Oesophagostomum radiatum, (adult and L4)
Lungworm (adult and L4) – Dictyocaulus viviparus.
Warbles (parasitic stages) – Hypoderma bovis, Hypoderma lineatum.
Mange mites – Sarcoptes scabiei var. bovis. The product may also be used to reduce infection of the mange mite Chorioptes bovis, but complete elimination may not occur.
Sucking and biting lice – Linognathus vituli, Haematopinus eurysternus, Bovicola (Damalinia) bovis.
The product has persistent activity against infections acquired with Trichostrongylus axei and Cooperia spp. up to 14 days after treatment, but only in the case of group treatment; Ostertagia ostertagi and Oesophagostomuradiatum up to 21 days after treatment; Dictyocaulus viviparus up to 28 days after treatment. It also has persistent activity against horn flies (Haematobia irritans) for up to 28 days after treatment; partial efficacy against Haematobia irritans may last for up to 35 days post application.
Contra-indications
Do not use in cases of known hypersensitivity to the active ingredient.The product has been formulated for topical application specifically for cattle. It should not be administered to other species as severe adverse reactions including fatalities in dogs, may occur.
Special warnings for each target species
Do not treat cattle when their hide is wet.
Do not treat cattle if rain is expected, as rain within 2 hours of treatment may reduce efficacy.
Do not apply to areas of skin which have mange scabs or other lesions, or to areas contaminated with mud or manure.
Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:
-Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.
-Underdosing, which may be due to underestimation of body weight, misadministration of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.
Resistance to ivermectin has been reported in Ostertagia ostertagi in cattle. Therefore, the use of this product should be based on local (regional, farm) epidemiological information about susceptibility of this helminth species and recommendations on how to limit further selection for resistance to anthelmintics
Special precautions for use
Special precautions for use in animals
To avoid secondary reactions due to the death of Hypoderma larvae in the oesophagus or in the spine, it is recommended to administer the product at the end of warble fly activity and before the larvae reach their resting sites.
Cases of intolerance with fatal outcome are reported in dogs, especially Collies, old English Sheepdogs and related breeds or crosses, and also in turtles/tortoises.” Do not allow these species to come in contact with this product.
It is recommended to treat all animals within a herd or group.
The shedding of nematode eggs can continue for some time after treatment.
Close container after use.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
May be irritating to human skin and eyes and the user should be careful not to apply it to himself or other persons.
Operators should wear rubber gloves, boots, goggles and a waterproof coat when applying the product. Protective clothing should be washed after use.
As absorption through skin can occur, in the event of accidental skin contact, wash the affected area immediately with soap and water.
If accidental eye exposure occurs, flush the eyes immediately with water and get medical attention.
Do not smoke, eat or drink while handling the product.
Wash hands after use.
Use only in well ventilated areas or outdoors.
HIGHLY INFLAMMABLE, keep away from heat, sparks, open flame or other sources of ignition.
Adverse reactions
None known.
Use during pregnancy, lactation or lay
Studies in laboratory animals have shown neither embroyotoxic nor teratogenic effects with ivermectin.
Can be used during pregnancy and lactation provided that the milk is not intended for human consumption.
Interactions
Do not combine ivermectin treatment with vaccination against lungworms. If vaccinated animals are to be treated, treatment should not be carried out within a period of 28 days before or after vaccination.
