Chanazine 2%

Target Species Cattle, horses, dogs and cats. 4.2 Indications for use, specifying the target species Chanazine 2% is a sedative with analgesic and muscle relaxant properties for use in cattle, horses, dogs and cats in cases where sedation is required including: 1. Handling fractious animals e.g. for transportation. 2. Medical examinations e.g. X-ray examinations, removal of bandages; examination of the penis and oral cavity. 3. Premedication for minor superficial operations, and local or regional anaesthesia. 4. Elimination of defecation when examining and treating the vagina, uterus and hindquarters. 4.3 Contraindications Not in cases of gastro-intestinal obstruction. Do not administer by the intra-carotid route. Careful consideration should also be given before administering to animals exposed to stress conditions such as extreme heat, cold high altitude or fatigue. 4.4 Special warnings for each target species None Known 4.5 Special precautions for use i. Special precautions for use in animals Caution where pulmonary disease is suspected. ii. Special precautions to be taken by the person administering the veterinary medicinal product to animals Horses sedated with xylazine usually remain standing and may still kick with accuracy. Precaution should be taken to avoid accidental injection / self injection. 1. In the case of accidental oral intake or self-injection, seek medical advice immediately and show the package leaflet to the doctor but DO NOT DRIVE as sedation and changes in blood pressure may occur. 2. Avoid skin, eye or mucosal contact. 3. Immediately after exposure, wash the exposed skin with large amounts of fresh water. 4. Remove contaminated clothes that are in direct contact with the skin. 5. In the case of accidental contactof the product with eyes, rinse with large amounts of fresh water. If symptoms occur, seek the advice of a doctor. 6. If pregnant women handle the product, special caution should be observed not to self-inject as uterine contractions and decreased foetal blood pressure may occur after accidental systemic exposure. 7. Advice to Doctors: Xylazine is an alpha2-adrenoreceptor agonist. Symptoms after absorption may involve clinical effects including dose-dependent sedation, respiratory depression, brachycardia, hypotension, a dry mouth, and hyperglycaemia. Ventricular arrhythmias have also been reported. Respiratory and haemodynamic symptoms should be treated symptomatically. 4.6 Adverse reactions (frequency and seriousness) Following the use of Chanazine 2% in cattle profuse salivation, bloat and polyuria may occur. Tympany should be avoided in recumbent cattle by maintaining the animal in sternal recumbency. Provision should also be made for facilitating dependent drainage from the mouth to avoid inhalation asphyxia. Side effects such as bradycardia, cardiac arrhythmia and polyuria may occur in the horse. Following intravenous administration to horses a transient rise followed by a fall in blood pressure usually occurs. Vomiting is commonly observed in dogs and cats following use of the product. 4.7 Use during pregnancy, lactation and lay Chanazine 2% should not be administered during the later stages of pregnancy because of the risk of inducing premature parturition. As the safety of xylazine use during organogenesis has not been fully demonstrated by current methods it should be used with caution during the first month of pregnancy. 4.8 Interaction with other medications and other forms of interaction None known.
Vat Rate: 20%