Category: F
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Category | POM-V |
Temperature | Ambient |
MA/VM/EU No: | 10434/4050 |
Species |
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VMD Link | https://www.vmd.defra.gov.uk/productinformationdatabase/files/SPC_Documents/SPC_123612.PDF |
NOAH Link | |
Dosage | Amounts to be administered and administration route For oral administration only. For the stabilisation of feline hyperthyroidism prior to surgical thyroidectomy and for the long term treatment of feline hyperthyroidism, the recommended starting dose is 5 mg per day. Wherever possible, the total daily dose should be divided into two and administered morning and evening. Tablets should not be split. If, for reasons of compliance, once daily dosing with a 5 mg tablet is preferable, then this is acceptable although the 2.5 mg tablet given twice daily may be more efficacious in the short term. The 5 mg tablet is also suitable for cats requiring higher dose rates. 1.25 mg tablets are intended for use in cats that require particularly small doses of thiamazole, and to assist with dosage adjustments. Haematology, biochemistry and serum total T4 should be assessed before initiating treatment and after 3 weeks, 6 weeks, 10 weeks, 20 weeks, and thereafter every 3 months. At each of the recommended monitoring intervals, the dose should be titrated to effect according to the total T4 and to clinical response to treatment. Dose adjustments should be made in increments of 2.5 mg and the aim should be to achieve the lowest possible dose rate. If more than 10 mg per day is required animals should be monitored particularly carefully. The dose administered should not exceed 20 mg/day. For long term treatment of hyperthyroidism the animal should be treated for life. Overdose In tolerance studies in young healthy cats, the following dose-related clinical signs occurred at doses of up to 30 mg/animal/day: anorexia, vomiting, lethargy, pruritus and haematological and biochemical abnormalities such as neutropenia, lymphopenia, reduced serum potassium and phosphorus levels, increased magnesium and creatinine levels and the occurrence of anti-nuclear antibodies. At a dose of 30 mg/day some cats showed signs of haemolytic anaemia and severe clinical deterioration. Some of these signs may also occur in hyperthyroid cats treated at doses of up to 20 mg per day. Excessive doses in hyperthyroid cats may result in signs of hypothyroidism. This is however unlikely, as hypothyroidism is usually corrected by negative feedback mechanisms. Please refer to Adverse reactions. If overdosage occurs, stop treatment and give symptomatic and supportive care. |
Withdrawals |