Karidox 100Mg/Ml 1L

4.1. Target species Chicken (broilers) and pigs. 4.2. Indications for use, specifying the target species CHICKENS (BROILERS) Prevention and treatment of chronic respiratory disease (CRD) and mycoplasmosis caused by microorganisms sensitive to doxycycline. PIGS Prevention of clinical respiratory disease due to Pasteurella multocida and Mycoplasma hyopneumoniae sensitive to doxycycline. The presence of the disease in the herd should be established before treatment. 4.3. Contraindications Do not use in case of hypersensitivity to tetracyclines. Do not use in case of resistance to tetracyclines occurs. Do not use in animals with hepatic dysfunction. 4.4. Special warnings for each target species Sick animals may have a reduced appetite and altered drinking patterns and should, if necessary, be medicated parenterally. In cases of altered food or drinking water uptake, the concentrations should be adjusted in such a way that the recommended dosage is achieved. Do not administer to laying hens. 4.5. Special precautions for use Special precautions for use in animals Prolonged or repeated use of this veterinary medicinal product is discouraged. Attention should be paid to avoidance of stressful conditions and improvement of management practices and hygiene standards. Avoid administration in oxidised drinking equipment. Use of the product should be based on susceptibility testing of the bacteria isolated from the animal. If this is not possible, therapy should be based on local (regional and farm level) epidemiological information about susceptibility of the target bacteria, taking into account official national antimicrobial policies.Inappropriate use of the product may increase the prevalence of bacteria resistant to doxycycline and may decrease the effectiveness of treatment with tetracyclines, due to the potential for cross-resistance. Due to variability (time, geographical) in susceptibility of bacteria for doxycycline, bacteriological sampling and susceptibility testing of micro-organisms from diseased birds on farm are highly recommended. A high resistance rate of E.coli, isolated from chickens, against tetracyclines has been documented. Therefore the product should be used for the treatment of infections caused by E.coli only after susceptibility testing has been carried out. As eradication of the target pathogens may not be achieved, medication should therefore be combined with good management practices, e.g. good hygiene, proper ventilation, no overstocking. Special precautions to be taken by the person administering the veterinary medicinal product to animals Tetracyclines may – in very rare cases – induce photosensitivity and allergic reactions. Do not handle the product if you are hypersensitive to tetracyclines. Wear gloves, work overall and approved safety glasses. This product is acid and likely to be irritant. Avoid contact with skin and eyes. In case of contact with skin, rinse immediately with plenty of water. In case of contact with eyes, rinse immediately with copious amounts of water and seek medical advice. Do not smoke, eat or drink while handling this product. The product can be harmful by skin contact and inhalation and may cause eye irritation. In case of accidental ingestion seek medical advise and show the label to the doctor. If any symptom should appear, such as a cutaneous eruption, seek prompt medical advice. Swelling of the face, lips or eyes or respiratory difficulties are the most serious signs which require urgent medical attention. 4.6. Adverse reactions (frequency and seriousness) Allergic and photosensitivity reactions can occur. Intestinal flora may be affected if treatment is very prolonged, and this may result in digestive disturbance. If suspected adverse reactions occur, treatment should be discontinued. 4.7. Use during pregnancy, lactation or lay The product should not be used during pregnancy or lactation 4.8. Interaction with other medicinal products and other forms of interaction Doxycycline absorption may be reduced by the presence of high quantities of calcium, iron, magnesium or aluminium in the diet. Do not administer together with antacids, kaolin and iron preparations. Do not administer together with bactericidal antibiotics. The solubility of the product is pH dependent and will precipitate if mixed in alkaline solution Do not administer with milk replacers
Vat Rate: 20%